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首页 > 产品中心 > 培养基 > 小分子工具 > StemRD_IWP-2 O-酰基转移酶*抑制剂 2mg WNT家族

_IWP-2 O-酰基转移酶*抑制剂 2mg WNT家族

简要描述:英文名称: IWP-2
产品应用: WNT通路信号调控
中国俗称: IWP-2 抑制剂
注册品牌: StemRD
生产厂家: 美国StemRD公司
订购货号: IWP-02
规格型号: 2mg
保存温度: ﹣20℃
产品种类: 小分子工具
到货时间: 1~5天

  • 产品型号:StemRD
  • 厂商性质:代理商
  • 更新时间:2021-11-23
  • 访  问  量:1145
详细介绍

产品英文名称: IWP-2
产品中文名称: IWP-2


IWP-2 产品英文简述:
IWP-2:N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide, is a specific inhibitor of the O-acyltransferase Porcupine with IC50=27nM (Ref.). Inhibition blocks the production of Wnt proteins that require fatty acid modifications, thus disrupting Wnt-dependent signaling. Porcupine inhibitor represent a novel class of potential therapeutics for cancer and other WNT dependent diseases.


Ref: B. Chen, et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat. Chem. Biol. 5, 100 (2009)
 

Purity: Greater than 99.5% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.
Biological Activity: In a cell-based assay measuring the activation of the TCF reporter gene, this compound gives IC50 of 30 nM.


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